Currently, more than 700,000 people are infected world-wide and the length of treatment of at least one year can complicate its application. Yet the disease remains a persistent public health issue in certain regions in India and Brazil. "Resistant cases are extremely rare for leprosy." But a more stable bacillus responds more efficiently to treatment regardless of the strain. Frequent mutation by a bacterium often leads to disturbing resistances to antibiotic treatments, such as with tuberculoses.
In the case of HIV, mutations are so frequent that it is almost possible to say whether a person was infected in Geneva or in Lausanne," explains Stewart Cole, "but in the case of leprosy, the most we can do is place the infection on a continental scale." But this is not bad news. It is one of the most stable organisms ever observed, even if half of its genome is dead." There are only around a hundred different variations between the DNA of two different strains, whereas with HIV or the flu there may be thousands of difference mutations. "The results of our analysis are surprising," says Cole, "the difference between the different strains is very small. There is little doubt that the bacillus originated in East Africa - Stewart Cole will examine this hypothesis in a future study - and then mutated into the four different strains. The most probable explanation is that the strain was carried by traders along the Silk Road." "One of the most interesting surprises is the discovery that the bacteria found in China are of European origin," explains Stewart Cole, "and one would have naturally expected the Indian strain. In Brazil, the West African strain is dominant, a probable consequence of the slave trade, but we also find the European strain - brought most likely from colonization.
Other examples in the study include Madagascar where, in spite of its geographic proximity to the African coast, the Indian strain is found on the island, where the majority of the inhabitants are of Indian origin. Their current distribution around the world echoes the history of population movements. The four strains of the leprosy bacilli that the scientific team found are: European, East African, West African and Indian. With humans being the only possible vessel for the bacteria, it naturally navigated along with man throughout the trade routes of the seas. Not necessarily surprising, for the Pharaonic Empire was economically and culturally tied to the old continent. "A person infected with the bacteria shows specific signs of bone deformations, like hands gripped closed in the form of a claw," explains Steward Cole, "and these clues helped us determine if we were dealing with the bodies of people who died from the disease."Įven though Egypt is geographically close to East Africa, where one of the four strains of leprosy comes from, DNA from a 4th century mommy shows traces of the European strain. The scientists started with the past history of the disease by investigating the remains of English, Croatian, and Bulgarian medieval cemeteries along with an ancient Egyptian burial site to find traces of the bacteria's DNA. Geneticists, microbiologists, and even archeologists have followed the bacteria's traces from their lab to the Silk Road and the tombs of Egyptian mummies.
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